Hemolysin produced by group B Streptococcus agalactiae
نویسندگان
چکیده
منابع مشابه
Lysis of erythrocytes by a hemolysin produced by a group B Streptococcus sp.
An improved procedure for the isolation and purification of the hemolysin produced by a group B streptococcus was developed, and the inactivation of partially purified hemolysin by several enzymes was studied. Hemolysin obtained in buffer containing starch and Tween 80 was inactivated by subtilisin and alpha-amylase, suggesting that the hemolysin may consist of a protein hemolytic moiety comple...
متن کاملTransposon mutagenesis of group B streptococcus beta-hemolysin biosynthesis.
Beta-hemolysin production by group B streptococci (GBS) is speculated to be a major virulence factor of the organism. A virulent, beta-hemolytic group B streptococcus strain was mutagenized with the self-conjugative transposon Tn916 to derive isogenic strains with mutations only in the gene(s) responsible for beta-hemolysin biosynthesis. There was no significant difference between the virulence...
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Several strains of group B Streptococcus agalactiae were found to be lethal for young adult rats. When bacteria were heat killed and then injected intraperitoneally into rats, rapid death (14 to 18 h) of the rats occurred, characterized by labored breathing, hemolyzed serum, hemoglobinuria, and subungual hemorrhages. Sections of tissues from these rats failed to reveal the cause of death. Rats ...
متن کاملHeterogeneity of hemolysin expression during neonatal Streptococcus agalactiae sepsis.
The beta-hemolysin of Streptococcus agalactiae is a major virulence factor; consequently, nonhemolytic strains rarely cause infections. We report on a case of neonatal sepsis caused by a strain displaying heterogeneous hemolysin expression. It was detected by the simultaneous isolation of hemolytic and nonhemolytic colonies from cultures of the infant's blood.
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Introduction: Streptococcus agalactiae (Group B Streptococcus or GBS), now recognized as a qualified infectious disease pathogen (QIDP) by the FDA, remains the leading cause of morbidity and mortality among infants in the United States. Although the incidence of GBS in pregnancy has decreased, penicillin and ampicillin minimal inhibitory concentrations (MICs) for GBS have risen, requiring highe...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1983
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1983.tb00265.x